Classifying insulin regimens--difficulties and proposal for comprehensive new definitions.
Identifieur interne : 003044 ( Main/Exploration ); précédent : 003043; suivant : 003045Classifying insulin regimens--difficulties and proposal for comprehensive new definitions.
Auteurs : A. Neu [Allemagne] ; K. Lange [Allemagne] ; T. Barrett [Royaume-Uni] ; F. Cameron [Australie] ; H. Dorchy [Belgique] ; H. Hoey [Irlande (pays)] ; P. Jarosz-Chobot [Pologne] ; H B Mortensen [Danemark] ; J-J Robert [France] ; K. Robertson [Koweït] ; C. De Beaufort [Luxembourg (pays)]Source :
- Pediatric diabetes [ 1399-5448 ] ; 2015.
Descripteurs français
- KwdFr :
- Adolescent, Association de médicaments (normes), Association médicamenteuse, Calendrier d'administration des médicaments, Consensus, Diabète de type 1 (traitement médicamenteux), Enfant, Guides de bonnes pratiques cliniques comme sujet, Humains, Hypoglycémiants (administration et posologie), Hypoglycémiants (usage thérapeutique), Insuline (administration et posologie), Insuline (usage thérapeutique), Médecine de l'adolescent (), Médecine individualisée, Pédiatrie (), Référenciation, Terminologie comme sujet.
- MESH :
- administration et posologie : Hypoglycémiants, Insuline.
- normes : Association de médicaments.
- traitement médicamenteux : Diabète de type 1.
- usage thérapeutique : Hypoglycémiants, Insuline.
- Adolescent, Association médicamenteuse, Calendrier d'administration des médicaments, Consensus, Enfant, Guides de bonnes pratiques cliniques comme sujet, Humains, Médecine de l'adolescent, Médecine individualisée, Pédiatrie, Référenciation, Terminologie comme sujet.
English descriptors
- KwdEn :
- Adolescent, Adolescent Medicine (methods), Benchmarking, Child, Consensus, Diabetes Mellitus, Type 1 (drug therapy), Drug Administration Schedule, Drug Combinations, Drug Therapy, Combination (standards), Humans, Hypoglycemic Agents (administration & dosage), Hypoglycemic Agents (therapeutic use), Insulin (administration & dosage), Insulin (therapeutic use), Pediatrics (methods), Practice Guidelines as Topic, Precision Medicine, Terminology as Topic.
- MESH :
- chemical , administration & dosage : Hypoglycemic Agents, Insulin.
- chemical , therapeutic use : Hypoglycemic Agents, Insulin.
- chemical : Drug Combinations.
- drug therapy : Diabetes Mellitus, Type 1.
- methods : Adolescent Medicine, Pediatrics.
- standards : Drug Therapy, Combination.
- Adolescent, Benchmarking, Child, Consensus, Drug Administration Schedule, Humans, Practice Guidelines as Topic, Precision Medicine, Terminology as Topic.
Abstract
Modern insulin regimens for the treatment of type 1 diabetes are highly individualized. The concept of an individually tailored medicine accounts for a broad variety of different insulin regimens applied. Despite clear recommendations for insulin management in children and adolescents with type 1 diabetes there is little distinctiveness about concepts and the nomenclature is confusing. Even among experts similar terms are used for different strategies. The aim of our review--based on the experiences of the Hvidoere Study Group (HSG)--is to propose comprehensive definitions for current insulin regimens reflecting current diabetes management in childhood and adolescence. The HSG--founded in 1994--is an international group representing 24 highly experienced pediatric diabetes centers, from Europe, Japan, North America and Australia. Different benchmarking studies of the HSG revealed a broad variety of insulin regimens applied in each center, respectively. Furthermore, the understanding of insulin regimens has been persistently different between the centers since more than 20 yr. Not even the terms 'conventional' and 'intensified therapy' were used consistently among all members. Besides the concepts 'conventional' and 'intensified', several other terms for the characterization of insulin regimens are in use: Basal Bolus Concept (BBC), multiple daily injections (MDI), and flexible insulin therapy (FIT) are most frequently used, although none of these expressions is clearly or consistently defined. The proposed new classification for insulin management will be comprehensive, simple, and catchy. Currently available terms were included. This classification may offer the opportunity to compare therapeutic strategies without the currently existing confusion on the insulin regimen.
DOI: 10.1111/pedi.12275
PubMed: 25865149
Affiliations:
- Allemagne, Australie, Belgique, Danemark, France, Irlande (pays), Koweït, Luxembourg (pays), Pologne, Royaume-Uni
- Angleterre, Midlands de l'Ouest, Région de Bruxelles-Capitale, Victoria (État), Île-de-France
- Birmingham, Bruxelles, Melbourne, Paris
- Université de Birmingham
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Le document en format XML
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Neu</name><affiliation wicri:level="1"><nlm:affiliation>Children's Hospital, University Hospital Tuebingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Children's Hospital, University Hospital Tuebingen</wicri:regionArea><wicri:noRegion>University Hospital Tuebingen</wicri:noRegion><wicri:noRegion>University Hospital Tuebingen</wicri:noRegion><wicri:noRegion>University Hospital Tuebingen</wicri:noRegion></affiliation></author><author><name sortKey="Lange, K" sort="Lange, K" uniqKey="Lange K" first="K" last="Lange">K. Lange</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Psychology OE5430, Hannover Medical School, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medical Psychology OE5430, Hannover Medical School</wicri:regionArea><wicri:noRegion>Hannover Medical School</wicri:noRegion><wicri:noRegion>Hannover Medical School</wicri:noRegion><wicri:noRegion>Hannover Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Barrett, T" sort="Barrett, T" uniqKey="Barrett T" first="T" last="Barrett">T. 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Cameron</name><affiliation wicri:level="3"><nlm:affiliation>Department of Endocrinology and Diabetes, Royal Children's Hospital, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Endocrinology and Diabetes, Royal Children's Hospital, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Dorchy, H" sort="Dorchy, H" uniqKey="Dorchy H" first="H" last="Dorchy">H. Dorchy</name><affiliation wicri:level="3"><nlm:affiliation>Clinique de Diabetologie, Hopital Universitaire des Enfants, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Clinique de Diabetologie, Hopital Universitaire des Enfants, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Hoey, H" sort="Hoey, H" uniqKey="Hoey H" first="H" last="Hoey">H. Hoey</name><affiliation wicri:level="1"><nlm:affiliation>Department of Paediatrics, University of Dublin, Trinity College, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Paediatrics, University of Dublin, Trinity College</wicri:regionArea><wicri:noRegion>Trinity College</wicri:noRegion></affiliation></author><author><name sortKey="Jarosz Chobot, P" sort="Jarosz Chobot, P" uniqKey="Jarosz Chobot P" first="P" last="Jarosz-Chobot">P. Jarosz-Chobot</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Endocrinology and Diabetes, Medical University of Silesia, Katowice, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pediatrics, Endocrinology and Diabetes, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Mortensen, H B" sort="Mortensen, H B" uniqKey="Mortensen H" first="H B" last="Mortensen">H B Mortensen</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Health Science, University of Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Faculty of Health Science, University of Copenhagen</wicri:regionArea><wicri:noRegion>University of Copenhagen</wicri:noRegion></affiliation></author><author><name sortKey="Robert, J J" sort="Robert, J J" uniqKey="Robert J" first="J-J" last="Robert">J-J Robert</name><affiliation wicri:level="3"><nlm:affiliation>Department of Diabetes in Children and Adolescents, Hôpital Necker - Enfants Malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Diabetes in Children and Adolescents, Hôpital Necker - Enfants Malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Robertson, K" sort="Robertson, K" uniqKey="Robertson K" first="K" last="Robertson">K. Robertson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Paediatrics, DCRTD, Kuwait.</nlm:affiliation><country xml:lang="fr">Koweït</country><wicri:regionArea>Department of Paediatrics, DCRTD</wicri:regionArea><wicri:noRegion>DCRTD</wicri:noRegion></affiliation></author><author><name sortKey="De Beaufort, C" sort="De Beaufort, C" uniqKey="De Beaufort C" first="C" last="De Beaufort">C. De Beaufort</name><affiliation wicri:level="1"><nlm:affiliation>DECCP, Clinique Pédiatrique/CHL, Luxembourg.</nlm:affiliation><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>DECCP, Clinique Pédiatrique/CHL</wicri:regionArea><wicri:noRegion>Clinique Pédiatrique/CHL</wicri:noRegion></affiliation></author></analytic><series><title level="j">Pediatric diabetes</title><idno type="eISSN">1399-5448</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adolescent Medicine (methods)</term><term>Benchmarking</term><term>Child</term><term>Consensus</term><term>Diabetes Mellitus, Type 1 (drug therapy)</term><term>Drug Administration Schedule</term><term>Drug Combinations</term><term>Drug Therapy, Combination (standards)</term><term>Humans</term><term>Hypoglycemic Agents (administration & dosage)</term><term>Hypoglycemic Agents (therapeutic use)</term><term>Insulin (administration & dosage)</term><term>Insulin (therapeutic use)</term><term>Pediatrics (methods)</term><term>Practice Guidelines as Topic</term><term>Precision Medicine</term><term>Terminology as Topic</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Association de médicaments (normes)</term><term>Association médicamenteuse</term><term>Calendrier d'administration des médicaments</term><term>Consensus</term><term>Diabète de type 1 (traitement médicamenteux)</term><term>Enfant</term><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Hypoglycémiants (administration et posologie)</term><term>Hypoglycémiants (usage thérapeutique)</term><term>Insuline (administration et posologie)</term><term>Insuline (usage thérapeutique)</term><term>Médecine de l'adolescent ()</term><term>Médecine individualisée</term><term>Pédiatrie ()</term><term>Référenciation</term><term>Terminologie comme sujet</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hypoglycemic Agents</term><term>Insulin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hypoglycemic Agents</term><term>Insulin</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Drug Combinations</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Hypoglycémiants</term><term>Insuline</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Diabetes Mellitus, Type 1</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Adolescent Medicine</term><term>Pediatrics</term></keywords><keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Association de médicaments</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Drug Therapy, Combination</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Diabète de type 1</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Hypoglycémiants</term><term>Insuline</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Benchmarking</term><term>Child</term><term>Consensus</term><term>Drug Administration Schedule</term><term>Humans</term><term>Practice Guidelines as Topic</term><term>Precision Medicine</term><term>Terminology as Topic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Association médicamenteuse</term><term>Calendrier d'administration des médicaments</term><term>Consensus</term><term>Enfant</term><term>Guides de bonnes pratiques cliniques comme sujet</term><term>Humains</term><term>Médecine de l'adolescent</term><term>Médecine individualisée</term><term>Pédiatrie</term><term>Référenciation</term><term>Terminologie comme sujet</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Modern insulin regimens for the treatment of type 1 diabetes are highly individualized. The concept of an individually tailored medicine accounts for a broad variety of different insulin regimens applied. Despite clear recommendations for insulin management in children and adolescents with type 1 diabetes there is little distinctiveness about concepts and the nomenclature is confusing. Even among experts similar terms are used for different strategies. The aim of our review--based on the experiences of the Hvidoere Study Group (HSG)--is to propose comprehensive definitions for current insulin regimens reflecting current diabetes management in childhood and adolescence. The HSG--founded in 1994--is an international group representing 24 highly experienced pediatric diabetes centers, from Europe, Japan, North America and Australia. Different benchmarking studies of the HSG revealed a broad variety of insulin regimens applied in each center, respectively. Furthermore, the understanding of insulin regimens has been persistently different between the centers since more than 20 yr. Not even the terms 'conventional' and 'intensified therapy' were used consistently among all members. Besides the concepts 'conventional' and 'intensified', several other terms for the characterization of insulin regimens are in use: Basal Bolus Concept (BBC), multiple daily injections (MDI), and flexible insulin therapy (FIT) are most frequently used, although none of these expressions is clearly or consistently defined. The proposed new classification for insulin management will be comprehensive, simple, and catchy. Currently available terms were included. This classification may offer the opportunity to compare therapeutic strategies without the currently existing confusion on the insulin regimen.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Danemark</li><li>France</li><li>Irlande (pays)</li><li>Koweït</li><li>Luxembourg (pays)</li><li>Pologne</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Midlands de l'Ouest</li><li>Région de Bruxelles-Capitale</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Birmingham</li><li>Bruxelles</li><li>Melbourne</li><li>Paris</li></settlement><orgName><li>Université de Birmingham</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Neu, A" sort="Neu, A" uniqKey="Neu A" first="A" last="Neu">A. Neu</name></noRegion><name sortKey="Lange, K" sort="Lange, K" uniqKey="Lange K" first="K" last="Lange">K. Lange</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Barrett, T" sort="Barrett, T" uniqKey="Barrett T" first="T" last="Barrett">T. Barrett</name></region></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Cameron, F" sort="Cameron, F" uniqKey="Cameron F" first="F" last="Cameron">F. Cameron</name></region></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Dorchy, H" sort="Dorchy, H" uniqKey="Dorchy H" first="H" last="Dorchy">H. Dorchy</name></region></country><country name="Irlande (pays)"><noRegion><name sortKey="Hoey, H" sort="Hoey, H" uniqKey="Hoey H" first="H" last="Hoey">H. Hoey</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Jarosz Chobot, P" sort="Jarosz Chobot, P" uniqKey="Jarosz Chobot P" first="P" last="Jarosz-Chobot">P. Jarosz-Chobot</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Mortensen, H B" sort="Mortensen, H B" uniqKey="Mortensen H" first="H B" last="Mortensen">H B Mortensen</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Robert, J J" sort="Robert, J J" uniqKey="Robert J" first="J-J" last="Robert">J-J Robert</name></region></country><country name="Koweït"><noRegion><name sortKey="Robertson, K" sort="Robertson, K" uniqKey="Robertson K" first="K" last="Robertson">K. Robertson</name></noRegion></country><country name="Luxembourg (pays)"><noRegion><name sortKey="De Beaufort, C" sort="De Beaufort, C" uniqKey="De Beaufort C" first="C" last="De Beaufort">C. De Beaufort</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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